How to use and side effects
Metering mode is selected individually depending on age and body weight.
For adults the initial dose is 600 mg / day with subsequent increase in dose of 200 mg every 3 days to achieve optimal effect. Multiplicity of reception - 1-2 times / day. The maximum recommended dose of 1-2 g / day.
Tablets should be swallowed whole, washed down with sips of water.
Elderly patients dosing regimen valparin XP is similar to the dosing regimen for adults and selected individually.
For children weighing over 20 kg initial dose - 400 mg / day. The dose should increase gradually to optimum values - usually 20-30 mg / kg / day in 1 or 2 divided doses.
Children weighing 20 kg should not be used valparin XP.
Side effectOn the part of the digestive system: rarely - nausea, vomiting, diarrhea and / or constipation, hepatitis, pancreatitis. Allergic reactions: seldom - skin rash, itching, photosensitivity, erythema multiforme, Stevens-Johnson syndrome. From the side of the central nervous system: rarely - ataxia, tremor, impaired consciousness, coma. On the part of the reproductive system: rarely - menstrual cycle, secondary amenorrhea. On the part of the hemopoietic system: rarely - anemia, thrombocytopenia, neutropenia, leukopenia, a decrease of fibrinogen, inhibition of platelet aggregation. Other: 2-12% - Hair loss, rarely - an increase of body weight, ammoniemia, creatinemia.
- Severe dysfunction of the pancreas;
- Acute or chronic hepatitis, active hepatitis cases in a family history (especially medicinal origin);
- Lactation (breastfeeding);
- Children under 3 years;
- Hypersensitivity to valproic acid and other components of the drug.
Should be regular monitoring of transaminases, bilirubin content, blood platelets, amylase (every 3 months).
Valproic acid inhibits platelet aggregation, which increases the risk of increased blood clotting time, bleeding. Keep in mind the possibility of complications related to bleeding in the postoperative period in patients receiving sodium valproate. Chronic administration of sodium valproate may develop spontaneous bruising and bleeding. In this case, you should immediately stop taking the drug.
Sodium valproate can cause pancreatitis medication and abnormal liver function (usually in the first 6 months of application). In this connection is necessary during the first 23 months of treatment to monitor the status of the pancreas, liver function tests to conduct, monitor the level of prothrombin. Abnormal liver function, hepatic failure during therapy with sodium valproate is sometimes observed in children with epilepsy and combined metabolic and degenerative diseases, organic pathology of the brain tissue and impaired cognitive development. If you experience symptoms such as an expression of weakness, lethargy, swelling, vomiting and jaundice should immediately stop using the product.
Effects on ability to drive vehicles and management mechanisms
The patient should be cautious when working with machinery, as drug reduces the ability to concentrate.
Reported rare cases of accidental or intentional overdose of the drug.
Symptoms: nausea, vomiting, dizziness, diarrhea, respiratory depression, hyporeflexia, coma.
Treatment: gastric lavage, activated charcoal method. If necessary - with the inpatient treatment of symptomatic therapy, hemodialysis.